Related Experiment Video
Updated: Jan 22, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis
Bethan Lloyd-Lewis1, Philippos Mourikis2, Silvia Fre1
1Institut Curie, PSL Research University, Inserm, CNRS, Paris, France; Sorbonne University, UPMC University of Paris VI, Paris, France.
Abstract:
During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.
Related Concept Videos
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
What is Cell Signaling?
Coordination Number and Geometry
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
Morphogenesis

