Related Experiment Video
Updated: Jan 22, 2026
09:02
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
Published on: August 10, 2020
7.9K
Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization
Rana M F Sammour1,2, Muhammad Taher3, Bappaditya Chatterjee1
1Pharmaceutical Technology Department, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.
Pharmaceutics
|July 21, 2019
Summary
This study optimized proniosomal aceclofenac formulations using various carriers. Maltodextrin-based proniosomes showed enhanced solubility, indicating potential for improved drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Proniosomal systems enhance bioavailability for poorly water-soluble drugs.
- Aceclofenac is used for pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis.
Purpose of the Study:
- To develop and optimize proniosomal aceclofenac formulations using different carriers.
- To evaluate the physical characteristics and drug compatibility of the prepared proniosomes.
Main Methods:
- Proniosomes prepared using the slurry method with carriers: maltodextrin, mannitol, and glucose.
- Characterization included DSC, FTIR, XRD, and SEM.
- Drug content and entrapment efficiency analyzed using HPLC.
Main Results:
- Compatibility of aceclofenac with carriers confirmed by DSC and FTIR.
- XRD confirmed the amorphous nature of proniosomes.
- Maltodextrin-based proniosomes demonstrated superior solubility compared to other formulations.
Conclusions:
- Proniosomal aceclofenac formulations can be successfully prepared using various carriers.
- Maltodextrin shows promise as a carrier for enhancing aceclofenac solubility in proniosomal systems.
Related Concept Videos
01:24Electron Carriers
91.5K
Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
91.5K
01:14Piaget's Stage 1 of Cognitive Development
1.6K
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...
Exploration...
1.6K
01:21Carrier Transport
925
The generation of electrical current in semiconductors is fundamentally driven by two mechanisms: drift and diffusion. These processes are essential for the functionality and performance of semiconductor-based devices.
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
925
01:06Carrier-Mediated Transport
1.2K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
1.2K
01:22Carrier Generation and Recombination
1.2K
Carrier generation is the process by which electron-hole pairs (EHPs) are created within the semiconductor. In direct-bandgap semiconductors, such as gallium arsenide (GaAs), this occurs efficiently when energy absorption prompts valence electrons to leap into the conduction band, leaving behind holes.
This process is given by the generation rate G and is efficient due to the conservation of momentum between the valence band maximum and conduction band minimum.
Indirect generation involves an...
This process is given by the generation rate G and is efficient due to the conservation of momentum between the valence band maximum and conduction band minimum.
Indirect generation involves an...
1.2K
01:42The ADP/ATP Carrier Protein
4.2K
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
4.2K