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HIV - Old Foe with a New Face
Sumeet Prakash Mirgh1, Vikas A Mishra2, Rishit Harbada3
1Trainee, 1st year, AIIMS, New Delhi.
The Journal of the Association of Physicians of India
|July 21, 2019
Summary
A middle-aged man on Anti-Retroviral therapy (ART) developed neurological symptoms. Doctors diagnosed him with CD8 encephalitis, a rare, treatable condition previously unreported in India.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- A middle-aged, HIV-positive male patient on second-line Anti-Retroviral therapy (ART) presented with neurological symptoms.
- The patient was virologically well-suppressed, indicating effective management of HIV infection.
Observation:
- The patient exhibited a subacute onset of neurological symptoms.
- Cerebrospinal fluid (CSF) analysis and neuroimaging were performed to investigate the symptoms.
Findings:
- The diagnostic workup revealed CD8 encephalitis, a rare neurological condition.
- This diagnosis represents a new, treatable entity within the spectrum of HIV-associated neurological disorders.
Implications:
- This case highlights the importance of considering CD8 encephalitis in patients with neurological symptoms, even when virologically suppressed.
- The report signifies the first documented case of CD8 encephalitis in India, expanding the geographical understanding of this rare condition.
- Early diagnosis and treatment of CD8 encephalitis are crucial for favorable patient outcomes.

