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Next generation probiotics in disease amelioration.
Chih-Jung Chang1,2, Tzu-Lung Lin1, Yu-Ling Tsai1
1Microbiota Research Center and Emerging Viral Infections Research Center, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan.
Journal of Food and Drug Analysis
|July 21, 2019
Summary
Next-generation probiotics (NGP) show promise in treating chronic inflammation-related diseases by restoring gut microbiota balance. These beneficial bacteria offer new therapeutic avenues beyond traditional probiotics.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- Gut microbiota dysbiosis is linked to chronic inflammatory diseases like colitis, obesity, diabetes, and cancer.
- Traditional probiotics have limited efficacy in managing these conditions.
Purpose of the Study:
- To explore the potential of next-generation probiotics (NGP) as therapeutic agents.
- To highlight the role of gut microbiota modulation in treating inflammation-related diseases.
Main Methods:
- Review of recent scientific literature on gut microbiota and next-generation probiotics.
- Identification of specific NGP strains and their associated health benefits.
Main Results:
- Several NGP, including Prevotella copri, Christensenella minuta, Akkermansia muciniphila, and Faecalibacterium prausnitzii, demonstrate potential in managing metabolic disorders, obesity, and intestinal diseases.
- Bacteroides fragilis shows anti-inflammatory and anti-cancer properties.
Conclusions:
- Next-generation probiotics represent a promising therapeutic strategy for inflammation-related diseases.
- Maintaining gut microbiota normobiosis is crucial for intestinal integrity and overall health homeostasis.
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