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Fetal neurology: Principles and practice with a life-course perspective
1Division of Pediatric Neurology, Case Western Reserve University, Cleveland, OH, United States.
Handbook of Clinical Neurology
|July 21, 2019
Summary
A fetal/neonatal neurology program integrates developmental origins of health and disease and life-course science. This approach enhances early diagnosis and predicts brain health using epigenetics and neuroinformatics for lifelong care.
Area of Science:
- Neurology
- Developmental Neuroscience
- Epigenetics
Background:
- Fetal/neonatal neurology programs integrate clinical, educational, and research components.
- Developmental origins of health and disease and life-course science are key principles.
- Prenatal factors influence fetal and neonatal neurological health.
Purpose of the Study:
- To establish a fetal/neonatal neurology program framework.
- To leverage epigenetics and life-course science for predicting brain health.
- To enhance early diagnosis and lifelong management of neurological disorders.
Main Methods:
- Integrating maternal, fetal, and placental data.
- Utilizing animal models and birth cohort studies on epigenetics.
- Developing age-specific neuroinformatics databases.
Main Results:
- Prenatal consultations offer critical insights into early brain development.
- Epigenetics aids in understanding gene-environment interactions for brain health prediction.
- Neuroinformatics databases improve identification of at-risk individuals.
Conclusions:
- Fetal neurology consultations are vital during sensitive developmental periods.
- Early diagnosis and intervention maximize neuroplasticity.
- Integrated data approaches enable personalized preventive and reparative treatments across the lifespan.
Keywords:
Developmental originsEpigeneticsFetal neurologyGene–environmentLife courseMaternal diseaseNeuroinformaticsNeurotherapeuticsPlacental diseaseMore Related Videos
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