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Hemofiltration clearance of flecainide in a patient with acute renal failure
A Borgeat1, J Biollaz, B Freymond
1Service d'Anesthésiologie et de Réanimation, Centre Hospitalier Universitaire, Lausanne, Switzerland.
Intensive Care Medicine
|January 1, 1988
Abstract:
Flecainide, a new antiarrhythmic drug, has been shown not no be removed to a significant extent by hemodialysis or peritoneal dialysis, in spite of a high renal clearance. Its systemic and hemofiltrate clearances, measured in a patient under continuous hemofiltration, were 402 and 19.7 ml/min respectively. The clearance ratio of less than 5% makes the contribution of hemofiltration to the elimination of flecainide clinically negligible.