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Co-relation Between Total Cholesterol, High Density Lipoprotein, Low Density Lipoprotein and Glycosylated Haemoglobin

D C Pant1, A B Mowar2, N Chandra3

  • 1Professor,Department of Medicine, SRMSIMS, Bareilly, Uttar Pradesh.

The Journal of the Association of Physicians of India
|July 21, 2019
PubMed

Insights

Diabetic patients with acute coronary syndrome (ACS) have higher HbA1c, LDL, and total cholesterol, and lower HDL. Controlling these markers reduces ACS severity in diabetics.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Diabetes mellitus and dyslipidemia significantly increase the risk of coronary artery disease (CAD).
  • Acute coronary syndrome (ACS) is a life-threatening manifestation of CAD in these high-risk patients.

Purpose of the Study:

  • To investigate the correlation between glycemic control (HbA1c) and lipid profiles (total cholesterol, LDL, HDL) in diabetic patients presenting with ACS.
  • To assess the relationship between these metabolic markers and the severity of ACS.

Main Methods:

  • Blood samples from 51 diabetic patients with ACS were analyzed for HbA1c and lipid profiles.
  • All patients underwent coronary angiography to determine CAD severity.
  • Statistical analysis was performed to correlate metabolic markers with ACS characteristics.

Main Results:

  • A significant direct correlation was observed between HbA1c, LDL, total cholesterol, and ACS severity (single vs. multi-vessel disease).
  • An inverse correlation was found between HDL levels and ACS severity.
  • Elevated HbA1c and LDL, along with low HDL, were associated with more severe coronary artery disease.

Conclusions:

  • Maintaining optimal glycemic control (HbA1c) is crucial for reducing ACS incidence and severity in diabetic patients.
  • Effective management of lipid profiles, particularly lowering LDL and increasing HDL, is essential for mitigating cardiovascular risk in this population.
Abstract

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