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Updated: Jan 22, 2026

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
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A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

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MiR-183 delivery attenuates murine lupus nephritis-related injuries via targeting mTOR

Xiuzhen Li1, Feng Luo2, Jie Li1

  • 1Department of Nephrology, Liaocheng People's Hospital, Liaocheng, China.

Scandinavian Journal of Immunology
|July 21, 2019
PubMed

Insights

MicroRNA-183 (miR-183) injection shows promise in treating systemic lupus erythematosus (SLE). This study found that miR-183 reduced disease markers and extended lifespan in a mouse model of SLE.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant morbidity.
  • MicroRNAs (miRNAs) are implicated in the pathogenesis of various human diseases, including SLE.
  • Understanding miRNA roles offers potential for novel therapeutic strategies in SLE.

Purpose of the Study:

  • To investigate the therapeutic potential of miR-183 injection in a mouse model of SLE.
  • To assess the impact of miR-183 on disease progression markers and survival.

Main Methods:

  • Utilized the MRL/lpr mouse model for spontaneous SLE development.
  • Administered miR-183 via intraperitoneal injection.
  • Quantified miR-183 and mTOR mRNA expression using real-time PCR.
  • Monitored lifespan, anti-dsDNA antibodies, urinary albumin, blood urea nitrogen (BUN), and T cell populations (Tregs and Th17).

Main Results:

  • miR-183 injection significantly reduced anti-dsDNA antibody and immune complex levels.
  • Restored the balance of regulatory T (Tregs) and T helper 17 (Th17) cell populations.
  • Prolonged the survival of MRL/lpr mice.
  • miR-183 expression correlated with mTOR mRNA levels.

Conclusions:

  • miR-183 injection demonstrates therapeutic efficacy in mitigating SLE progression.
  • This miRNA-based therapy may offer a novel approach to managing SLE.
  • Further research into miR-183 as a treatment for SLE is warranted.
Keywords:
lupus nephritismTORmiR-183miRNAs-based therapysystemic lupus erythematosus

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