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Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in

Mike Zangenberg1,2, Øystein H Johansen3,4, Alemseged Abdissa5

  • 1Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Tropical Medicine & International Health : TM & IH
|July 21, 2019
PubMed

Insights

Prolonged and persistent diarrhea (ProPD) is common in children with diarrhea, affecting 14% of cases. Importantly, most children with ProPD do not have acute malnutrition, indicating a need for further research and specific treatment guidelines.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Diarrheal diseases remain a significant global health challenge in children.
  • Prolonged and persistent diarrhea (ProPD) represents a distinct clinical entity with potential implications for nutritional status.
  • Understanding the prevalence and associated factors of ProPD is crucial for effective management.

Purpose of the Study:

  • To determine the prevalence of prolonged (ProD) and persistent diarrhea (PD) in children under five presenting with diarrhea.
  • To investigate the co-occurrence of ProPD with acute malnutrition.
  • To identify demographic and clinical factors associated with ProPD.

Main Methods:

  • A case-control study was conducted with children under five years old.
  • Cases had diarrhea; controls did not, matched by age and district.
  • Data were analyzed using mixed model logistic regression.

Main Results:

  • Out of 1134 cases, 11% had ProD and 3.2% had PD.
  • Children with diarrhea were more likely to have acute malnutrition (17%) and premature birth (5.7%) compared to controls.
  • Crucially, approximately 75% of prolonged and persistent diarrhea (ProPD) cases did not present with acute malnutrition.

Conclusions:

  • Prolonged and persistent diarrhea (ProPD) is a common condition among children with diarrhea.
  • ProPD is not exclusively associated with acute malnutrition.
  • Further research is needed to understand the causes of ProPD in both malnourished and well-nourished children to develop targeted treatment guidelines.
Abstract

Keywords:
diarrhée persistantediarrhée prolongéemalnutrition aiguë modéréemalnutrition aiguë sévèremoderate acute malnutritionpersistent diarrhoeaprolonged diarrhoeasevere acute malnutrition

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