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Updated: Jan 22, 2026
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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
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Preoperative plasma fibrinogen as a predictive factor for post-tonsillectomy haemorrhage
Stefan Grasl1, Stefan Janik1, Erich Vyskocil1
1Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.
Summary
Elevated preoperative plasma fibrinogen levels (PFL) predict severe post-tonsillectomy hemorrhage. High PFL identifies patients at increased risk for bleeding after tonsillectomy, aiding in preoperative screening.
Area of Science:
- Otolaryngology
- Surgical Hemorrhage Research
- Diagnostic Biomarkers
Background:
- Post-tonsillectomy hemorrhage (PTH) is a common complication.
- Predictive markers for severe PTH are crucial for patient management.
Purpose of the Study:
- To evaluate preoperative plasma fibrinogen levels (PFL) as a predictor of severe post-tonsillectomy hemorrhage (PTH).
Main Methods:
- Retrospective chart review of 456 patients undergoing tonsillectomy.
- Comparison of preoperative PFL in patients with and without severe bleeding requiring surgical revision.
Main Results:
- Severe bleeding occurred in 9.2% of patients.
- Significantly higher PFL were observed in patients with severe bleeding (P=.023).
- Elevated PFL was an independent predictor of PTH (HR 2.66 univariate, HR 15.4 multivariable).
- High PFL showed a 95.1% negative predictive value for identifying patients at lower risk.
Conclusions:
- Elevated preoperative plasma fibrinogen is a significant prognostic factor for severe post-tonsillectomy hemorrhage.
- PFL can serve as a reliable preoperative screening marker to identify patients at higher risk for PTH.
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