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Ocular mucins in dry eye disease
Céline Portal1, Valérie Gouyer1, Frédéric Gottrand1
1Inserm, Univ. Lille, CHU Lille, LIRIC UMR 995, Lille, F-59000, France.
Experimental Eye Research
|July 21, 2019
Summary
Dry eye disease involves mucin changes affecting ocular surface integrity. This review covers mucin production in dry eye and available mouse models for research.
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Dry eye disease is a prevalent, multifactorial condition impacting ocular surface health worldwide.
- Key features include water loss, reduced glycocalyx mucin expression, and goblet cell loss, affecting tear film stability.
- Mucins, complex glycoproteins, are crucial for ocular surface protection and integrity, though their tear film organization is not fully understood.
Purpose of the Study:
- To review current knowledge on ocular surface mucin production in healthy states and dry eye disease.
- To provide an overview of mouse models utilized for studying mucins in the context of dry eye disease.
Main Methods:
- Literature review of studies on ocular mucin production.
- Compilation and summary of existing mouse models relevant to dry eye mucin research.
Main Results:
- Dry eye disease is characterized by specific alterations in mucin expression and goblet cell function.
- Various genetically modified and spontaneously occurring mouse models exhibit ocular defects relevant to dry eye research.
Conclusions:
- Ocular mucins are critical but under-studied components of the ocular surface.
- Mouse models are essential tools for advancing the understanding of mucin's role in dry eye disease and for developing new therapies.
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