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Seaweeds-derived compounds modulating effects on signal transduction pathways: A systematic review
Claudia Juárez-Portilla1, Tatiana Olivares-Bañuelos2, Tania Molina-Jiménez3
1Centro de Investigaciones Biomédicas, Universidad Veracruzana. Av. Dr. Luis Castelazo Ayala s/n. Col. Industrial Ánimas, C.P. 91190, Xalapa, Veracruz, México.
Summary
Marine seaweeds yield bioactive compounds that modulate cell signaling pathways, offering potential for new drug development. This review details their molecular mechanisms and therapeutic applications for diseases like cancer and diabetes.
Area of Science:
- Marine Biology
- Pharmacology
- Natural Products Chemistry
Background:
- Marine natural products, particularly from seaweeds, are gaining attention for their significant biological activities.
- Seaweed-derived bioactive compounds can modulate critical cell signaling pathways implicated in various diseases.
- Understanding these molecular mechanisms is crucial for developing seaweed-based pharmaceuticals.
Purpose of the Study:
- To review the molecular mechanisms through which seaweed compounds exert their biological effects.
- To explore the potential utilization of these compounds in the design of novel therapeutic drugs.
- To provide a comprehensive overview of seaweed's pharmacological potential.
Main Methods:
- Systematic review conducted following PRISMA-P guidelines.
- Searched four databases (SCOPUS, PubMed, Wiley, EBSCO) using defined keywords.
- 113 articles published between 2005 and 2018, focusing on cell line and animal models, were included after rigorous selection and quality assessment.
Main Results:
- Identified key modulated signaling pathways including L-Arginine/NO, TNF-α, MAPKs, PI3K/AKT/GSK, mTOR, NF-κB, apoptosis, cell cycle, MMPs, and Nrf2.
- Seaweeds were sourced from 15 countries, with a notable concentration from Eastern regions.
- Analysis revealed moderate risk of bias, with noted limitations in reporting sample collection details, size, and experimental blinding.
Conclusions:
- Summarized information on seaweed-derived compounds and extracts with demonstrated biological activity.
- Highlighted the role of these compounds in modulating various signal pathways.
- Emphasized the potential of seaweed-derived compounds for developing future treatments for cancer, diabetes, and inflammation-related diseases.
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