Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

641
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
641
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1.9K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.9K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.7K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.7K
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

2.0K
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
2.0K
Ion Channels01:19

Ion Channels

91.2K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.2K
Roles of Electrolytes: Sodium and Potassium01:24

Roles of Electrolytes: Sodium and Potassium

1.9K
Sodium plays a crucial role in maintaining fluid and electrolyte balance and overall bodily homeostasis. Sodium balance is primarily regulated by kidney function, which adjusts sodium elimination to match dietary intake and maintain proper electrolyte levels. Sodium is the most abundant cation in the extracellular fluid (ECF) and is found in salts such as sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). Although cellular plasma membranes are relatively impermeable to sodium, its role in...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Vertigo and oculomotor disorders: diagnosis, anatomical classification and etiology].

Die Ophthalmologie·2026
Same author

Frequency and phenotype of GAA-FGF14 disease in bilateral vestibulopathy syndromes: insights from repeat expansion carriers, including a case of co-occurrence with RFC1-related CANVAS.

Journal of neurology·2026
Same author

Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain.

Kidney medicine·2026
Same author

Benign Paroxysmal Positional Vertigo: The Case for Renaming It Peripheral Paroxysmal Positional Vertigo.

Neurology·2026
Same author

Liquid Chromatography-Mass Spectrometry-Based Molecular Profiling of Vertigoheel.

International journal of molecular sciences·2026
Same author

A precise atlas of the human subcortex.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 21, 2026

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.6K

Potassium channels in omnipause neurons.

Ümit S Mayadali1, Karoline Lienbacher2, Michael Mustari3

  • 1Institute of Anatomy and Cell Biology I, Ludwig-Maximilian University (LMU), Munich, Germany; German Center for Vertigo and Balance Disorders, LMU, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), LMU, Munich, Germany.

Progress in Brain Research
|July 22, 2019
PubMed
Summary

This study maps potassium channel expression in brainstem neurons essential for eye movements. Findings reveal similar patterns in monkeys and humans, suggesting a basis for saccadic disorders.

Keywords:
Fast-firing neuronsHumanImmunohistochemistryK(V)1.1K(V)3.1bMonkeyPerineuronal netsPotassium-chloride cotransporterSaccade

More Related Videos

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

15.6K
Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

10.6K

Related Experiment Videos

Last Updated: Jan 21, 2026

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.6K
High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

15.6K
Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

10.6K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Potassium (K+) channels are crucial for neuronal excitability and action potential generation.
  • Omnipause neurons (OPNs) are vital components of the premotor circuitry controlling saccadic eye movements.

Purpose of the Study:

  • To determine the immunoreactivity profile of specific potassium channels and transporters in OPNs.
  • To compare the expression patterns of these channels in monkey and human brains.

Main Methods:

  • Histochemical analysis of monkey and human brainstem sections.
  • Immunohistochemistry using antibodies against KV1.1, KV3.1b, and K+-Cl- cotransporter (KCC2).

Main Results:

  • OPNs in both species showed positive immunoreactivity for KV1.1, KV3.1b, and KCC2.
  • KV3.1b was localized to the somatic membrane and proximal dendrites.
  • KV1.1 was primarily found on the soma, while KCC2 was prominent in distal dendrites.

Conclusions:

  • Consistent K+-channel expression patterns in OPNs across species were observed.
  • Altered K+-channel expression in OPNs may underlie saccadic disorders due to neuronal dysfunction.