Related Experiment Video
Updated: Jan 21, 2026
06:04
Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
Published on: July 16, 2019
9.0K
Rebound nystagmus, a window into the oculomotor integrator
Jorge Otero-Millan1, Ayse I Colpak2, Amir Kheradmand3
1Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States.
Progress in Brain Research
|July 22, 2019
Summary
Rebound nystagmus, a cerebellar sign, arises from two distinct mechanisms: one visual and one non-visual. Further research will clarify the non-visual component
Area of Science:
- Neuroscience
- Ophthalmology
- Cerebellar Function
Background:
- Rebound nystagmus is a common cerebellar sign.
- It is a transient nystagmus occurring after prolonged eccentric gaze.
- Its precise generation mechanism, potentially involving the oculomotor neural integrator, remains unclear.
Purpose of the Study:
- To investigate the underlying mechanisms of rebound nystagmus.
- To test hypotheses regarding the generation of this oculomotor phenomenon.
Main Methods:
- Combined experimental data with mathematical modeling.
- Analyzed rebound nystagmus in healthy subjects under conditions with and without visual fixation.
Main Results:
- Identified two contributing mechanisms for rebound nystagmus.
- One mechanism is visually dependent, while the other is not.
Conclusions:
- Rebound nystagmus generation involves both visual and non-visual pathways.
- Future studies should elucidate the nature of the non-visual signals (eye position vs. velocity) and their origin (afferent vs. efferent).
More Related Videos
Related Concept Videos
01:29Definite Integral
39
Consider a real-valued function defined on a closed interval. One of the fundamental objectives in calculus is to determine the area under the graph of such a function. When an exact computation is not readily available, this area can be estimated by dividing the interval into a finite number of equal subintervals. Each subinterval corresponds to a rectangle whose width is the length of the subinterval and whose height is determined by the value of the function at a selected point within that...
39
01:25Indefinite Integrals
59
The water inflow rate into a storage tank is not constant but increases over time. Initially, the pump delivers water at a rate of 5 L/min. However, the inflow rate increases by 2 L/min for each additional minute due to rising pressure or system adjustments. This scenario can be described mathematically by a linear function:It is necessary to integrate the inflow rate function to measure the total volume of water added to the tank over time. The total water volume V(t) is obtained by performing...
59
01:13Integrator and Differentiator
1.4K
Op-amp circuits have significant applications in various fields, including automotive engineering. One such application is cruise control systems in cars, where op-amp circuits are integral for maintaining a constant speed. In these systems, op-amps function as both integrators and differentiators.
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
1.4K
01:20Integrated Healthcare System
2.3K
An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
2.3K
02:39The Integrated Rate Law: The Dependence of Concentration on Time
41.0K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
41.0K
01:30Properties of Definite Integral I
34
A car’s motion over time can be effectively analyzed using integral calculus, particularly through the concept of the definite integral applied to a velocity–time relationship. The definite integral describes how velocity accumulates over a specified time interval to produce total displacement. From a geometric perspective, this displacement is interpreted as the area under the velocity–time curve. Several key properties of definite integrals make it easier to analyze motion...
34