Related Experiment Video
Updated: Jan 21, 2026

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice
Published on: September 16, 2020
Skeletal Stability After Mandibular Counterclockwise Rotational Advancement for Correction of Skeletal Class II
Supawadee Hasprayoon1, Yu-Fang Liao1, Yuh-Jia Hsieh1
1Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
Objectives:
The aim of this systemic review was to compare surgical and postsurgical changes in the mandible after bilateral sagittal split osteotomy (BSSO) with counterclockwise (CCW) rotational advancement. A review of the current available dental literature regarding skeletal stability after mandibular CCW rotational advancement for skeletal Class II deformity was performed using a qualitative and quantitative analysis (meta-analysis).
Material And Methods:
Five databases were searched: PubMed, MEDLINE (Ovid), Science Direct, Scopus, and Web of Science. The systematic review and meta-analysis addressed the stability of BSSO CCW rotational advancement and the effect of the amount of CCW rotation on skeletal stability after BSSO advancement. Meta-analysis was performed only for studies reporting point B position in mm or mandibular plane angle in degrees before and after surgery and at follow-up.
Results:
The database search resulted in 284 articles after removal of duplicates, and an additional 3 articles were included from hand searches of the bibliographies of the selected articles and relevant reviews. Eight studies were included in the systematic review; all were retrospective case series, and all used rigid fixation. Only 1 study was of medium quality; all other studies were of low quality. Meta-analysis of 3 studies revealed a mean forward movement of 7.6 mm at point B (95% confidence interval [CI], 4.07 to 11.4), a mean downward movement of 2.6 mm (95% CI, -0.66 to 5.84), and a mean CCW rotation of mandibular plane of 4.3° (95% CI, -6.34 to -2.19) during surgery. After surgery, point B showed a mean backward movement of -0.18 mm (95% CI, -1.30 to 1.14), a mean upward movement of -0.5 mm (95% CI, -3.00 to 1.98), and a mean clockwise rotation of 0.1° (95% CI, -1.76 to 1.91).
Conclusions:
Meta-analysis showed mandibular CCW rotational advancement is a stable procedure, both horizontally and vertically. However, the conclusions are far from robust due to the small sample size and poor quality of the reviewed studies.
Related Concept Videos
Classification of Skeletal Muscle Fibers
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
What is the Skeletal System?
Introduction to the Skeletal System
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
The Functions of the Skeletal System
Skeletal Muscle Anatomy
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

