Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

2.3K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
2.3K
Plasma Membrane in Bacteria and Archaea01:27

Plasma Membrane in Bacteria and Archaea

1.7K
The plasma membrane is an essential cellular structure responsible for maintaining cellular integrity and regulating the selective transport of molecules. While bacteria and archaea share the fundamental function of plasma membranes, their structural and molecular differences reflect adaptations to distinct ecological and physiological challenges.Bacterial Plasma MembranesBacterial plasma membranes are predominantly composed of phospholipids with fatty acid chains ester-linked to a glycerol...
1.7K
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

16.6K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
16.6K
Introduction to Membrane Proteins01:16

Introduction to Membrane Proteins

80.7K
The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
80.7K
Composition of Blood Plasma01:24

Composition of Blood Plasma

7.9K
Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
7.9K
The Resting Membrane Potential01:21

The Resting Membrane Potential

142.0K
Overview
142.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free chiral self-propelled robots compared to active Brownian circle swimmers.

Physical review. E·2026
Same author

Reliability of a nonlinear fluctuation-dissipation relation as a test of Markovianity.

Physical review. E·2026
Same author

Time-energy trade-off in stochastic resetting using optimal control.

Physical review. E·2026
Same author

Probing the limits of effective temperature consistency in actively driven systems.

Soft matter·2026
Same author

Harnessing non-equilibrium forces to optimize work extraction.

Nature communications·2025
Same author

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 21, 2026

Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry
05:39

Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry

Published on: November 7, 2010

27.1K

Flow Arrest in the Plasma Membrane.

Michael Chein1, Eran Perlson1, Yael Roichman2

  • 1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Biophysical Journal
|July 22, 2019
PubMed
Summary

Cell membrane receptor arrangement impacts cellular sensing. We studied neurotrophin receptor (TrkB and p75) diffusion in neuronal cells, finding their motion is confined but correlated within membrane domains.

More Related Videos

Author Spotlight: Exploring Plasma Membrane Repair Mechanisms with Innovative Thermoplasmonic Puncturing
06:32

Author Spotlight: Exploring Plasma Membrane Repair Mechanisms with Innovative Thermoplasmonic Puncturing

Published on: January 19, 2024

1.7K
Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry
05:39

Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry

Published on: November 7, 2010

27.1K
Author Spotlight: Exploring Plasma Membrane Repair Mechanisms with Innovative Thermoplasmonic Puncturing
06:32

Author Spotlight: Exploring Plasma Membrane Repair Mechanisms with Innovative Thermoplasmonic Puncturing

Published on: January 19, 2024

1.7K
Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.7K

Area of Science:

  • Cell Biology
  • Biophysics
  • Neuroscience

Background:

  • Receptor arrangement in the plasma membrane is crucial for cellular sensing, influencing sensitivity and spatial resolution.
  • The mechanical properties and structure of the cell membrane dictate the spatial and temporal organization of receptors.

Purpose of the Study:

  • To characterize membrane flow dynamics in response to embedded protein motion.
  • To investigate the correlated diffusion of transmembrane neurotrophin receptors (TrkB and p75) in neuronal cells.

Main Methods:

  • Utilized extracellularly tagged receptors TrkB and p75 on transfected neuronal cells.
  • Measured correlated diffusion of these receptors to analyze membrane dynamics.

Main Results:

  • Observed transient confinement of single receptor motion to submicron domains, consistent with previous findings.
  • Confirmed long-range correlations in receptor motion within the plasma membrane, aligning with fluid membrane hydrodynamics predictions.
  • Discovered that these correlations decay exponentially, with a decay length comparable to the average domain size, deviating from predictions of persistent long-range correlations.

Conclusions:

  • Receptor motion in the plasma membrane is confined to specific domains.
  • While membrane hydrodynamics predict long-range correlations, these are limited by domain size and decay exponentially.
  • This finding refines our understanding of how membrane mechanics influence receptor organization and cellular signaling.