Stimulating the left dorsolateral prefrontal cortex improves the memory representation of threats among individuals...

Prior research has suggested that individuals with high avoidant attachment may demonstrate a vigilant attentional bias and selective attentional avoidance towards attachment-related negative information (threat information). Similarly, some evidence suggests that impairment of hot working memory (WM) or emotional-related WM occurs in highly avoidant individuals. Moreover, functional MRI studies have demonstrated that the less-activated left dorsolateral prefrontal cortex (L-DLPFC) is related to the impairment of cognitive control for threat stimuli in individuals with high avoidant attachment. Therefore, in the present study, the causal role of the L-DLPFC on hot WM presentation was investigated by the high-definition transcranial direct current stimulation (HD-tDCS) technique, and cognitive control for internal mental representations in WM was measured by the Internal Shift Task (IST). The results showed that the highly avoidant participants performed faster on the emotional IST than low avoidant participants in the sham condition. In the emotional IST, highly avoidant participants were slower after receiving anodal HD-tDCS than in the sham condition. Moreover, the switching cost of the emotional IST was significantly smaller in the highly avoidant group than low avoidant group under the sham HD-tDCS condition. Interestingly, in the emotional IST, the switching cost of highly avoidant individuals was significantly greater in the anodal stimulation group than the sham stimulation group. Conversely, the switching cost of low avoidant individuals was significantly smaller with anodal stimulation than for sham stimulation. The findings indicate that anodal HD-tDCS over the L-DLPFC can effectively enhance the ability of memory representation towards threat information in highly avoidant individuals. This study extends causal research by showing that the L-DLPFC is an important brain region for hot WM representations.