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Published on: January 12, 2019
Long-term outcomes of functional neurological disorder in children
Joseph Raper1, Victoria Currigan1, Sarah Fothergill2
1Paediatric Neurology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Insights
Functional neurological disorder (FND) in children is more common than previously thought. While many children experience symptom remission, a significant portion may develop FND or similar symptoms in adulthood.
Area of Science:
- Neurology
- Pediatrics
- Psychiatry
Background:
- Functional neurological disorder (FND) is a common reason for pediatric neurology referrals.
- Long-term outcomes and adult recurrence rates for pediatric FND are not well-established.
Purpose of the Study:
- To determine the incidence of pediatric FND.
- To investigate the long-term outcomes of pediatric FND, including adult symptom recurrence.
Main Methods:
- Retrospective chart review of pediatric neurology patients with FND.
- Record linkage with Child and Adolescent Mental Health Services.
- Review of adult medical records for functional symptoms.
Main Results:
- 124 children met criteria; common presentations included seizures, sensory loss, and motor symptoms.
- Incidence in pediatric neurology services was 6 per 100,000 children under 16.
- Over a median follow-up of 8.3 years, 23% of eligible individuals showed evidence of FND in adulthood.
Conclusions:
- Pediatric FND is more common than previously estimated.
- Despite specialist referral, a high long-term remission rate is observed in this pediatric FND cohort.
Objectives:
To establish the incidence and long-term outcomes (up to 21 years) of children presenting to a University hospital paediatric neurology service with symptoms due to functional neurological disorder (FND) with particular reference to occurrence of FND or similar symptoms in adulthood.
Methods:
Retrospective chart review to determine characteristics of the original paediatric FND presentation plus record-linkage with providers of Child and Adolescent Mental Health Services. Chart review of adult medical records for documentation of functional symptoms in adulthood.
Results:
124 individuals (56% female) met entry criteria. The most common presentations were seizures (18%), sensory loss (18%) and motor symptoms (16%). Frequency gradually increased with age of onset with an incidence in paediatric neurological services of 6 per 100 000 children under 16. In up to 21 years' follow-up (median 8.3 years), 114/124 attained their 16th birthdays by the study census date and were thus eligible for inclusion in an analysis of symptom persistence/recurrence in adulthood. 26/114 (23%) showed evidence of FND in adulthood of sufficient significance to be recorded in medical records.
Conclusion:
Paediatric FND is commoner than previous estimates. Even in this selected population of children reaching specialist paediatric neurology services, a high long-term remission rate is observed.
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