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Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO
Changyu Cao1, Haoji Zhang1, Kai Wang1
1College of Life Science, Foshan University, Foshan, 528231, Guangdong, People's Republic of China.
Abstract:
Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.
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