Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia

Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate fasciculus (Arc) and superior longitudinal fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure.