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Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors
1Pathology Department, Louisiana State University Medical School, Shreveport 71130.
Research Communications in Chemical Pathology and Pharmacology
|April 1, 1988
Abstract:
Binding of the D-amino acids D-5-hydroxytryptophan (D-5-HTP) and D-dihydroxyphenylalanine (D-DOPA) to high affinity sites for serotonin (5-HT) and dopamine (DA) was studied in bovine striatum. D-5-HT bound to the 5-HT site with affinity in the micromolar range, but showed no appreciable binding at the DA site. D-DOPA showed little binding to either 5-HT or DA receptors.