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Updated: Jan 21, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

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PI-RADS version 2: optimal time range for determining positivity of dynamic contrast-enhanced MRI in peripheral zone

H Bae1, N H Cho2, S Y Park3

  • 1Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Clinical Radiology
|July 23, 2019
PubMed
Abstract

Insights

Optimal dynamic contrast-enhanced MRI timing for prostate cancer detection is within 60-72 seconds. This analysis helps improve the accuracy of PI-RADSv2 scoring for clinically significant prostate cancer.

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE MRI) is crucial for prostate cancer (PCa) detection.
  • Optimizing imaging parameters is key to improving diagnostic accuracy.

Purpose of the Study:

  • To determine the optimal time cut-off for positivity in DCE MRI of peripheral zone (PZ) prostate cancer.
  • To evaluate the added value of DCE MRI in conjunction with diffusion-weighted imaging (DWI) for detecting clinically significant PCa (csPCa).

Main Methods:

  • Analysis of 89 patients with PZ PCa undergoing DWI and DCE MRI.
  • Experienced reader identified the best contrast time for tumor-to-normal tissue differentiation.
  • Cut-off times were established for csPCa based on Epstein criteria and ISUP grade ≥2.

Main Results:

  • Optimal time cut-offs for csPCa were ≤72 seconds (Epstein) and ≤56 seconds (ISUP grade ≥2).
  • Inter-reader agreement for DCE MRI positivity was substantial (kappa 0.622 and 0.527).
  • DCE MRI demonstrated significant added value (39.1-75%) in detecting csPCa.

Conclusions:

  • Imaging findings within 60-72 seconds post-contrast reliably determine DCE MRI positivity in PZ PCa.
  • This time window enhances the diagnostic performance of PI-RADSv2 for csPCa detection.

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