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Updated: Jan 21, 2026

Uracil-DNA Glycosylase Assay by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Analysis
Published on: April 22, 2022
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
Katja Scheffler1, Karine Øian Bjørås2, Magnar Bjørås3
1Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Norway; Clinic of Laboratory Medicine, St. Olavs Hospital, N-7491 Trondheim, Norway.
Abstract:
Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA damage is one of the causative factors of ageing and increases the risk of a wide range of neurological disorders. Base excision repair is the major pathway for removal of oxidized bases in the genome and initiated by DNA glycosylases. Emerging evidence suggest that DNA glycosylases have non-canonical functions important for genome regulation. Understanding canonical and non-canonical functions of DNA glycosylases processing oxidative base lesions modulating brain function will be crucial for the development of novel therapeutic strategies.
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