Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Wave Parameters01:10

Wave Parameters

9.1K
The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.1K
Distributions to Estimate Population Parameter01:26

Distributions to Estimate Population Parameter

5.0K
The accurate values of population parameters such as population proportion, population mean, and population standard deviation (or variance) are usually unknown. These are fixed values that can only be estimated from the data collected from the samples. The estimates of each of these parameters are sample proportion, the sample mean, and sample standard deviation (or variance). To obtain the values of these sample statistics, data are required that have particular distribution and central...
5.0K
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

437
The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's...
437
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

156
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
156
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

589
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
589
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

823
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
823

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

R3DG: Retrieve, Rank, and Reconstruction with Different Granularities for Multimodal Sentiment Analysis.

Research (Washington, D.C.)·2025
Same author

Differently Implicational Bandler-Kohout Subproduct Method.

IEEE transactions on cybernetics·2025
Same author

Triple dimensional psychology knowledge encouraging graph attention networks to exploit aspect-based sentiment analysis.

Scientific reports·2025
Same author

Cross-Modal Data Fusion via Vision-Language Model for Crop Disease Recognition.

Sensors (Basel, Switzerland)·2025
Same author

Dense skip-attention for convolutional networks.

Scientific reports·2025
Same author

ViE-Take: A Vision-Driven Multi-Modal Dataset for Exploring the Emotional Landscape in Takeover Safety of Autonomous Driving.

Research (Washington, D.C.)·2025
Same journal

A Multi-Head Attention Transformer Model for Wearable in Situ Fall Detection.

IEEE access : practical innovations, open solutions·2026
Same journal

Validating Single-Camera Pose Estimation Against Multi-Camera Motion Capture for Accessible Biomechanical Assessment.

IEEE access : practical innovations, open solutions·2026
Same journal

Learning to Diagnose Privately: DP-Powered LLMs for Radiology Report Classification.

IEEE access : practical innovations, open solutions·2026
Same journal

Radio-Frequency Toroid Susceptometry of Magnetic Nanoparticles: What Goes Around Comes Around.

IEEE access : practical innovations, open solutions·2026
Same journal

Cross-Architecture Knowledge Distillation for Histopathological Image Analysis.

IEEE access : practical innovations, open solutions·2026
Same journal

Mislabel Identification Using Transfer Learning-Based Ensemble Method.

IEEE access : practical innovations, open solutions·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

7.3K

A Robust Parameter-free Thresholding Method for Image Segmentation.

Xinhua Cao, Taihao Li, Hongli Li

    IEEE Access : Practical Innovations, Open Solutions
    |July 23, 2019
    PubMed
    Summary
    This summary is machine-generated.

    A new parameter-free image segmentation method enhances accuracy by optimizing class variance and mean distances. This robust technique offers consistent results across diverse applications, outperforming existing methods.

    Keywords:
    histogramobjective functionparameter-free thresholdingsegmentation

    More Related Videos

    Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
    08:52

    Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test

    Published on: April 21, 2021

    5.4K
    A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications
    06:40

    A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications

    Published on: December 28, 2021

    3.9K

    Related Experiment Videos

    Last Updated: Jan 21, 2026

    Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
    07:28

    Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

    Published on: January 21, 2017

    7.3K
    Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
    08:52

    Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test

    Published on: April 21, 2021

    5.4K
    A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications
    06:40

    A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications

    Published on: December 28, 2021

    3.9K

    Area of Science:

    • Computer Vision
    • Image Processing
    • Machine Learning

    Background:

    • Image segmentation is crucial for analyzing visual data.
    • Existing thresholding methods often struggle with class imbalance or variance differences.
    • Parameter-free methods are desirable for consistent and adaptable segmentation.

    Purpose of the Study:

    • To introduce a novel parameter-free thresholding method for image segmentation.
    • To address limitations of current methods in handling images with disparate class sizes or variances.
    • To develop a robust and easily adaptable image segmentation technique.

    Main Methods:

    • Developed a new objective function maximizing between-class variance and class-global mean distances.
    • The method is parameter-free, requiring no manual tuning.
    • Evaluated performance against Otsu, maximum entropy, and 2D Otsu methods.

    Main Results:

    • The proposed method demonstrated superior accuracy and robustness compared to standard techniques.
    • Achieved consistent segmentation results due to its parameter-free nature.
    • Validated on both simulated and real-world biomedical and photographic images.

    Conclusions:

    • The new parameter-free thresholding method offers a significant improvement for image segmentation.
    • Its objective function effectively handles variations in class size and variance.
    • The method's simplicity and robustness make it suitable for various applications.