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The Suppression of Prolactin is required for the Treatment of Advanced Prostate Cancer

Leslie C Costello1

  • 1Department of Oncology and Diagnostic Sciences; University of Maryland School of Dentistry; and the University of Maryland Greenebaum Comprehensive Cancer Center, USA.

Oncogen
|July 23, 2019
PubMed

Insights

A novel treatment targeting prolactin, a key driver of advanced prostate cancer, has shown promising results. Cabergoline therapy significantly reduced prolactin levels and terminated malignancy in one patient, offering hope for effective prostate cancer treatment.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Androgen-independent advanced prostate cancer is a fatal malignancy with no effective treatments.
  • Misconceptions regarding androgen receptor activity have hindered treatment development.
  • Emerging evidence links prolactin to the progression of androgen-independent prostate cancer.

Purpose of the Study:

  • To investigate the role of prolactin in advanced prostate cancer.
  • To determine if suppressing prolactin can be an effective treatment strategy.

Main Methods:

  • Administered cabergoline (a dopamine agonist) to a patient with advanced prostate cancer.
  • Monitored plasma prolactin levels before and during treatment.

Main Results:

  • Cabergoline treatment led to an 88% decrease in plasma prolactin.
  • The malignancy was terminated in the treated patient.
  • This suggests a potential new therapeutic approach.

Conclusions:

  • Prolactin plays a crucial role in advanced prostate cancer progression.
  • Suppressing prolactin with cabergoline may offer the first effective treatment for this condition.
  • Further studies are needed to confirm efficacy in a broader patient population.
Keywords:
MalignancyMetastasisProlactinProstate Cancer

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