Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rolling Without Slipping01:09

Rolling Without Slipping

5.2K
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is...
5.2K
Rolling With Slipping01:14

Rolling With Slipping

7.8K
Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can...
7.8K
Rolling Resistance01:21

Rolling Resistance

623
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
623
Mohr's Circle for Moments of Inertia: Problem Solving01:14

Mohr's Circle for Moments of Inertia: Problem Solving

3.2K
Mohr's circle is a graphical method for determining an area's principal moments by plotting the moments and product of inertia on a rectangular coordinate system. This circle can also be used to calculate the orientation of the principal axes.
Consider a rectangular beam. The moments of inertia of the beam about the x and y axis are 2.5(107) mm4 and 7.5(107) mm4, respectively. The product of inertia is 1.5(107) mm4. Determine the principal moments of inertia and the orientation of the major and...
3.2K
Mohr's Circle for Plane Stress01:23

Mohr's Circle for Plane Stress

1.2K
Mohr's circle is a graphical method for identifying the state of stress at a point in a material, making it easier to analyze stress transformations under plane stress conditions. This two-dimensional technique visualizes both normal and shearing stresses on an element.
Consider a set of Cartesian coordinates. The horizontal and vertical axes correspond to normal stress (σ) and shearing stress (τ), respectively. Two points, points A and B, are defined by the normal and shear...
1.2K
Mohr's Circle for Plane Strain01:18

Mohr's Circle for Plane Strain

1.2K
Mohr's circle is a crucial graphical method used to analyze plane strain by plotting strain on a set of cartesian coordinates, where the abscissa is normal strain ∈ and the ordinate is shear strain γ. Similarly to Mohr’s circle for plane stress, two points X and Y are plotted. Their coordinates are (∈x, -γXY) and (∈Y, γXY), respectively.
Mohr's circle visually represents the strain states under various conditions, which is essential for...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Lactiplantibacillus plantarum</i> P133, a Folate-Producing Probiotic, Ameliorates Cardiac Injury in Hyperhomocysteinemia Mice by Modulating Gut Microbiota and Serum Metabolome.

Foods (Basel, Switzerland)·2026
Same author

Golgi casein kinase-mediated phosphorylation of osteopontin orchestrates macrophage- lung-resident mesenchymal stem cells crosstalk and fibrogenesis: a targetable macromolecular axis.

International journal of biological macromolecules·2026
Same author

Ultrafast Hopping Transfer Enables High-Anion Conduction.

Journal of the American Chemical Society·2026
Same author

Predictive model for postoperative hyperalgesia in patients with lower limb fractures undergoing nerve block surgery.

Pakistan journal of medical sciences·2026
Same author

AL109933.1 inhibits hepatocellular carcinoma progression via downregulating the Warburg effect and inactivating the YY1/PKM2/PIK3R1/PI3K/AKT/ mTOR/HIF-1α axis.

Cellular signalling·2026
Same author

Lactobacillus reduction drives oxidative gut-liver adverse effects of heterogeneous aggregates polylactic acid nanoplastics and silica nanoparticles.

Food research international (Ottawa, Ont.)·2026
Same journal

[Recent progress and policy recommendations for biomanufacturing technology in China].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same journal

[CRISPR/Cas9-mediated knockout of the <i>Soc</i> gene in T4 bacteriophage and mutant construction].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same journal

[High-throughput fluorescence-activated droplet sorting of polyethylene terephthalate hydrolases based on fluorescent nanoparticle biosensors].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same journal

[Machine learning-optimized solid-state fermentation of non-grain biomass for enhanced feed protein production].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same journal

[Growth and metabolic characteristics and kinetic modeling of MDCK adherent cells cultured in basket bioreactors].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same journal

[Metabolic engineering of <i>Saccharomyces cerevisiae</i> for <i>de novo</i> biosynthesis of gibberellin A<sub>3</sub>].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

3.1K

[Progress in rolling circle amplification in biological detection].

Zhongxu Zhan1, Ju Liu1, Bolu Chen1

  • 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|July 23, 2019
PubMed
Summary
This summary is machine-generated.

Rolling circle amplification (RCA) is a fast, isothermal DNA amplification method. This paper details RCA design and its diverse applications in detecting pathogens, tumor markers, and viruses.

Keywords:
biological detectionisothermalrolling circle amplification

More Related Videos

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

17.3K

Related Experiment Videos

Last Updated: Jan 21, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

3.1K
Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

17.3K

Area of Science:

  • Molecular Biology
  • Biotechnology
  • Biochemistry

Background:

  • Rolling circle amplification (RCA) is a sensitive, isothermal DNA amplification technique.
  • RCA utilizes staining or probes to enhance detection signals.
  • This method is broadly applied in biological detection.

Purpose of the Study:

  • To introduce the design principles of rolling circle amplification.
  • To summarize recent applications of RCA in biological detection.
  • To discuss the future prospects of RCA technology.

Main Methods:

  • Review of rolling circle amplification design strategies.
  • Compilation of recent literature on RCA applications.
  • Analysis of RCA's utility in various detection scenarios.

Main Results:

  • RCA design involves specific primer and template considerations.
  • RCA has shown significant utility in detecting pathogens, nucleic acid tumor markers, proteins, small biomolecules, and viruses.
  • The technique offers a sensitive and rapid detection method.

Conclusions:

  • Rolling circle amplification is a versatile and powerful tool for molecular detection.
  • Further development of RCA holds promise for advancing diagnostics and research.
  • Optimized RCA protocols can enhance sensitivity and specificity across diverse applications.