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Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers
Published on: February 28, 2011
Novel cucurbitane-type triterpene saponins from Hemsleya amabilis
Na Wang1, Lin Yang2, Xin-Yue Guo2
1Neuropharmacology, College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Abstract:
The rhizomes of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded three new cucurbitane-type triterpene saponins xuedanosides K-M (1-3) by silica gel column, ODS column, and pre-HPLC techniques. The structure was determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1-3 were evaluated for cytotoxic activity against HeLa and HCT-8 human cancer cell lines and showed significant cytotoxicity with IC50 values of 2.01-14.56 and 8.94-27.48 μM, respectively.
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