Nickel-Catalyzed Decarboxylative Generation and Asymmetric Allylation of 2-Azaallyl Anions
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Updated: Jan 21, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Chenlu Liu1, Changfeng Deng1, Han Yang1
1Key Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Science & Technology , Sichuan University , No. 29, Wangjiang Road , Chengdu 610064 , China.
Abstract:
The first nickel-catalyzed asymmetric decarboxylative allylation (DcA) of allyl 2,2-diarylglycinate imines is reported. This transformation utilizes a chiral ferrocenyl bidentate ligand and a Ni(0) precatalyst to mediate the decarboxylative generation and asymmetric allylation of 2-azaallyl anions, affording α-aryl homoallylic imines in modest-to-high yields and moderate-to-high enantiomeric ratios. The resulting Ni-catalyzed transformation proved to be less general in comparison to our previously reported analogous Pd-mediated protocol, but it still exhibited certain advantages in regard to the regio- and enantioselectivity of the C-C bond formation.
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