Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Packaging00:58

DNA Packaging

112.1K
Overview
112.1K
Chromatin Packaging02:21

Chromatin Packaging

21.8K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
21.8K
Chromatin Packaging01:32

Chromatin Packaging

18.9K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
18.9K
Chromatin Packaging02:21

Chromatin Packaging

9.6K
9.6K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

30.6K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient Quantum Dot Light-Emitting Diode Enabled by a Thick Inorganic CdS Interfacial Modification Layer.

ACS applied materials & interfaces·2023
Same author

Programmed Ultrafast Scan Welding of Cu Nanowire Networks with a Pulsed Ultraviolet Laser Beam for Transparent Conductive Electrodes and Flexible Circuits.

ACS applied materials & interfaces·2020
Same author

Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.

Frontiers in cell and developmental biology·2020
Same author

Effect of Black Tea Infusion on Physicochemical Properties, Antioxidant Capacity and Microstructure of Acidified Dairy Gel during Cold Storage.

Foods (Basel, Switzerland)·2020
Same author

UV/Chlorination of sulfamethazine (SMZ) and other prescription drugs: kinetics, transformation products and insights into the combined toxicological assessment.

Environmental technology·2020
Same author

Nanoscale integration of porphyrin in GroEL protein cage: Photophysical and photochemical investigation.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2020
Same journal

3DICE: Interpretable 3D Cross-Modal Learning for Drug-Target Interaction Prediction and Large-Scale Drug Discovery.

Bioinformatics (Oxford, England)·2026
Same journal

KASSPer: Kinase Active Site Structure Prediction using Protein and Ligand Language Models and Its Application to Virtual Screening.

Bioinformatics (Oxford, England)·2026
Same journal

IDR searcher: a search engine solution for public image resources.

Bioinformatics (Oxford, England)·2026
Same journal

KCFtools: Rapid alignment-free method for introgression screening and GWAS using k-mer profiles.

Bioinformatics (Oxford, England)·2026
Same journal

Meta2DB: Curated shotgun metagenomic feature sets and metadata for health state prediction.

Bioinformatics (Oxford, England)·2026
Same journal

conMItion: an R package adjusting confounding factors for associations in multi-omics.

Bioinformatics (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Genetic association testing using the GENESIS R/Bioconductor package.

Stephanie M Gogarten1, Tamar Sofer2,3, Han Chen4,5

  • 1Department of Biostatistics, University of Washington, Seattle, WA, USA.

Bioinformatics (Oxford, England)
|July 23, 2019
PubMed
Summary
This summary is machine-generated.

GENESIS is a new R package for analyzing genomic data. It efficiently performs association tests on genotype data stored in Genomic Data Storage (GDS) format using flexible mixed models.

More Related Videos

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

10.5K
Freezing, Thawing, and Packaging Cells for Transport
07:32

Freezing, Thawing, and Packaging Cells for Transport

Published on: July 2, 2008

13.0K

Related Experiment Videos

Last Updated: Jan 21, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K
Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

10.5K
Freezing, Thawing, and Packaging Cells for Transport
07:32

Freezing, Thawing, and Packaging Cells for Transport

Published on: July 2, 2008

13.0K

Area of Science:

  • Genomics
  • Statistical Genetics
  • Bioinformatics

Background:

  • Genomic Data Storage (GDS) format enables efficient storage and retrieval of large-scale genotype data.
  • Performing robust association tests requires flexible statistical models capable of handling complex genetic architectures.

Purpose of the Study:

  • To develop a software package, GENESIS, for comprehensive genomic association analyses.
  • To enable flexible mixed-model analyses directly on genotype data stored in GDS format.

Main Methods:

  • Development of the GENESIS R/Bioconductor package.
  • Implementation of single- and aggregate-variant association tests.
  • Integration of flexible mixed models with options for various link functions, variance components, and heteroskedasticity.

Main Results:

  • GENESIS provides efficient genotype data handling and association testing capabilities.
  • The package supports highly flexible mixed models for diverse genetic analyses.
  • Seamless integration with the R/Bioconductor ecosystem facilitates complete genomic analysis workflows.

Conclusions:

  • GENESIS offers a powerful and flexible tool for genomic association studies.
  • The package enhances the analysis of genotype data by leveraging the GDS format and advanced statistical modeling.
  • GENESIS streamlines the end-to-end genomic analysis process within the R environment.