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Updated: Jan 21, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Amyloidosis cutis dyschromica: report of 3 cases
Mozhdeh Sepaskhah, Kaveh Taghipour1, Amir Miri
1Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz Department of Dermatology, Shiraz University of Medical Sciences, Shiraz. kaveh109@hotmail.com.
Abstract:
Amyloidosis cutis dyschromica (ACD) is a rare pigmentary disorder with about 50 cases having been reported in the English literature. Only one case of ACD has been reported from Iran. We present three patients who presented with generalized hyper- and hypopigmented patches, sparing face, hands, and feet in all three cases. The presence of amorphous eosinophilic deposits in the papillary dermis confirmed the diagnosis of ACD; the deposits were stained by crystal violet in the histopathological examination of the lesions. In all three cases, similar lesions were present in some of the family members. ACD should be considered in the differential diagnosis of diffuse hyperpigmentation studded with hypopigmentation, especially when beginning in childhood.
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