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Hidradenitis suppurativa associated with sorafenib initiation

Daniel C Morse, Ramya Chockalingam, Allison Pye

  • 12Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX. aohuen@mdanderson.org.

Dermatology Online Journal
|July 23, 2019
PubMed

Insights

Sorafenib, a cancer drug, can cause skin issues. This report details a rare case of hidradenitis suppurativa (HS) developing after sorafenib treatment in a patient.

Area of Science:

  • Oncology
  • Dermatology

Background:

  • Sorafenib is a multi-kinase inhibitor used to treat renal cell carcinoma and hepatocellular carcinoma.
  • Cutaneous adverse reactions are common side effects associated with sorafenib therapy.

Observation:

  • A patient developed hidradenitis suppurativa (HS) after starting sorafenib treatment.
  • HS is characterized by recurrent painful nodules, abscesses, and draining sinus tracts, typically in the axilla and groin.

Findings:

  • This case presents hidradenitis suppurativa (HS) as a potential, previously unreported adverse cutaneous reaction to sorafenib.
  • The development of HS occurred in the axillary and inguinal skin folds.

Implications:

  • This finding expands the known spectrum of sorafenib-induced skin toxicities.
  • Clinicians should consider HS in patients on sorafenib presenting with relevant symptoms.
  • Further investigation into the mechanism of sorafenib-induced HS may be warranted.

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