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Hidradenitis suppurativa associated with sorafenib initiation
Daniel C Morse, Ramya Chockalingam, Allison Pye
12Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX. aohuen@mdanderson.org.
Dermatology Online Journal
|July 23, 2019
Summary
Sorafenib, a cancer drug, can cause skin issues. This report details a rare case of hidradenitis suppurativa (HS) developing after sorafenib treatment in a patient.
Area of Science:
- Oncology
- Dermatology
Background:
- Sorafenib is a multi-kinase inhibitor used to treat renal cell carcinoma and hepatocellular carcinoma.
- Cutaneous adverse reactions are common side effects associated with sorafenib therapy.
Observation:
- A patient developed hidradenitis suppurativa (HS) after starting sorafenib treatment.
- HS is characterized by recurrent painful nodules, abscesses, and draining sinus tracts, typically in the axilla and groin.
Findings:
- This case presents hidradenitis suppurativa (HS) as a potential, previously unreported adverse cutaneous reaction to sorafenib.
- The development of HS occurred in the axillary and inguinal skin folds.
Implications:
- This finding expands the known spectrum of sorafenib-induced skin toxicities.
- Clinicians should consider HS in patients on sorafenib presenting with relevant symptoms.
- Further investigation into the mechanism of sorafenib-induced HS may be warranted.
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