Linalool modulates dermatophyte susceptibility to azole drugs
Hellen Aparecida Silva Ponte1, Maria Islaine de Oliveira Lima1, Edeltrudes de Oliveira Lima2
1Laboratory of Biochemistry, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité, Brazil.
Medical Mycology
|July 23, 2019
Summary
The natural compound linalool enhances antifungal drug effectiveness against common fungal infections. Linalool and azole antifungals show synergistic effects, improving treatment outcomes.
Area of Science:
- Mycology
- Pharmacology
- Natural Products Chemistry
Background:
- Dermatophyte infections caused by Microsporum and Trichophyton species pose a significant health challenge.
- Emerging antifungal resistance necessitates novel therapeutic strategies.
- Ergosterol biosynthesis inhibitors (azoles) are common antifungal agents.
Purpose of the Study:
- To investigate the resistance-modulating activity of the monoterpene linalool.
- To evaluate the combined effects of linalool with azole antifungals (ketoconazole, fluconazole, itraconazole) against dermatophytes.
- To determine if linalool enhances the efficacy of existing antifungal treatments.
Main Methods:
- Minimum Inhibitory Concentration (MIC) determination using microdilution assays.
- Evaluation of linalool's modulating effect by testing azole MICs in the presence of subinhibitory linalool concentrations.
- Checkerboard assays to assess the synergistic interaction between linalool and azole drugs (ketoconazole, itraconazole).
Main Results:
- Fungal strains (Microsporum spp. and Trichophyton spp.) showed increased sensitivity to ketoconazole and itraconazole when combined with linalool.
- Synergistic interactions were observed between linalool and the azole antifungal drugs.
- Linalool demonstrated significant resistance-modulating activity.
Conclusions:
- Linalool can potentiate the activity of azole antifungals against dermatophytes.
- The combination of linalool with ketoconazole or itraconazole offers a promising synergistic approach for treating fungal infections.
- Linalool represents a potential adjuvant therapy to overcome antifungal resistance.
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