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Cardiac Insulin Resistance in Heart Failure: The Role of Mitochondrial Dynamics

Masao Saotome1, Takenori Ikoma2, Prottoy Hasan2

  • 1Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan. msaotome@hama-med.ac.jp.

International Journal of Molecular Sciences
|July 24, 2019
PubMed

Insights

Cardiac insulin resistance, often seen with type 2 diabetes mellitus (T2DM), contributes to heart failure (HF) progression. Targeting mitochondrial dynamics may improve cardiac function and metabolism in these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Mitochondrial Biology

Background:

  • Heart failure (HF) frequently coexists with insulin resistance and type 2 diabetes mellitus (T2DM).
  • Existing treatments for T2DM do not always improve cardiac outcomes, highlighting a gap in understanding cardiac insulin resistance.
  • Cardiac insulin resistance significantly contributes to HF pathogenesis and progression, yet lacks clinical definition and targeted treatments.

Purpose of the Study:

  • To review the correlation between cardiac insulin resistance and HF progression.
  • To discuss the role of mitochondrial dynamics in cardiac insulin resistance and HF.
  • To explore mitochondria-targeted interventions for improving cardiac metabolism and HF.

Main Methods:

  • Literature review of basic and clinical investigations.
  • Analysis of the role of mitochondrial dynamics in cellular homeostasis, energy production, and cell survival.
  • Discussion of potential therapeutic strategies targeting mitochondria.

Main Results:

  • Cardiac insulin resistance is a key factor in HF development and worsening.
  • Mitochondrial dynamics are crucial for maintaining myocardial energy production and cellular health.
  • Dysfunctional mitochondrial dynamics exacerbate cardiac insulin resistance and HF.

Conclusions:

  • Mitochondrial dynamics are integral to cardiac insulin resistance and HF pathogenesis.
  • Targeting mitochondrial dynamics offers a potential therapeutic avenue for improving myocardial insulin sensitivity, metabolism, and function.
  • Further research into mitochondria-targeted interventions could lead to novel treatments for HF in diabetic patients.

Keywords:
cardiac insulin resistanceheart failuremitochondrial dynamicstype 2 diabetes mellitus

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