Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

10.5K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
10.5K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.0K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.0K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

14.0K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
14.0K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.6K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

3.8K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.8K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.6K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereo-electroencephalography-guided responsive neuromodulation: A propensity-matched cohort study.

Epilepsia·2026
Same author

Matched-Pair Analysis of Patients With Large-Vessel Occlusions Undergoing Thrombectomy Using Single-Plane Versus Biplane Angiography.

Stroke (Hoboken, N.J.)·2026
Same author

Preoperative MR Perfusion and Intraoperative MR Imaging in Predicting Surgical Resectability and Quality of Life Outcomes in High-Grade Glioma Patients: A Prospective Cohort Analysis and Case Study.

Cureus·2026
Same author

Establishment of a Native Cavity-Nesting Bee (<i>Exoneura robusta</i>) After Translocation Into an Urban Environment.

Ecology and evolution·2026
Same author

Management and Outcomes of Traumatic Cerebral Venous Sinus Injury Among Patients With Traumatic Brain Injury and Concomitant Intracranial Hemorrhage.

Neurosurgery·2026
Same author

Identification of a therapeutic threshold for AAV-STXBP1 gene therapy in a rodent model of STXBP1 developmental and epileptic encephalopathy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Related Experiment Video

Updated: Jan 21, 2026

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
12:59

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

Published on: January 19, 2011

33.4K

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.

Arturo Andrade1, Ashton Brennecke2, Shayna Mallat2

  • 1Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA. Arturo.Andrade@unh.edu.

International Journal of Molecular Sciences
|July 24, 2019
PubMed
Summary

Voltage-gated calcium channels (CaVs) are genetically linked to psychiatric disorders. This review explores CaVs

Keywords:
anxietyattention-deficit and hyperactivity disorderautism spectrum disorderauxiliary subunitsbipolar disordercalcium channel modulatorsgenetic risk variationsmajor depressive disorderpsychiatric disordersschizophreniavoltage-gated calcium channels

More Related Videos

Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies
11:42

Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies

Published on: January 22, 2015

19.8K
Voltage and Calcium Dual Channel Optical Mapping of Cultured HL-1 Atrial Myocyte Monolayer
08:25

Voltage and Calcium Dual Channel Optical Mapping of Cultured HL-1 Atrial Myocyte Monolayer

Published on: March 23, 2015

10.8K

Related Experiment Videos

Last Updated: Jan 21, 2026

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
12:59

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

Published on: January 19, 2011

33.4K
Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies
11:42

Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies

Published on: January 22, 2015

19.8K
Voltage and Calcium Dual Channel Optical Mapping of Cultured HL-1 Atrial Myocyte Monolayer
08:25

Voltage and Calcium Dual Channel Optical Mapping of Cultured HL-1 Atrial Myocyte Monolayer

Published on: March 23, 2015

10.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Psychiatric disorders affect a significant portion of the global adult population.
  • Genetic factors are known to play a role in the development of psychiatric conditions.
  • Advances in genomic sequencing have improved the identification of genetic risk loci.

Purpose of the Study:

  • To review recent findings linking voltage-gated calcium channels (CaVs) and their subunits to psychiatric disorders.
  • To explore the role of CaVs in neuronal function and their association with mental health conditions.
  • To examine the potential of CaV modulators as therapeutic agents for psychiatric disorders.

Main Methods:

  • Comprehensive literature review of studies on CaVs and psychiatric disorders.
  • Analysis of genetic risk loci identified through genome sequencing.
  • Examination of functional studies and pharmacological evidence related to CaVs.

Main Results:

  • Several identified genetic risk loci for psychiatric disorders are located within genes encoding CaVs.
  • CaVs are critical for essential neuronal processes, suggesting a direct link to brain function.
  • Functional studies and pharmacological data support the involvement of CaVs in the pathophysiology of psychiatric conditions.

Conclusions:

  • Voltage-gated calcium channels and their auxiliary subunits represent a significant area of research in psychiatric disorders.
  • Understanding the role of CaVs offers potential for novel therapeutic strategies targeting these channels.
  • Further investigation into CaV pathophysiology is crucial for advancing treatments for mental health conditions.