Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.7K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

3.8K
3.8K
Increased Body Temperature01:25

Increased Body Temperature

6.4K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Increased pulse rate01:17

Increased pulse rate

1.1K
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
1.1K
What is Gene Expression?01:42

What is Gene Expression?

194.9K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
194.9K
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

3.3K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma.

Cell reports. Medicine·2026
Same author

RUNX1-deficiency drives immune-active ER<sup>+</sup> mammary tumorigenesis through activation of interferon signaling.

bioRxiv : the preprint server for biology·2026
Same author

LSD1 ablation promotes mammary tumor metastasis by attenuating NK cell-mediated anti-tumor immunity.

bioRxiv : the preprint server for biology·2026
Same author

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting.

bioRxiv : the preprint server for biology·2026
Same author

A Legacy of Mentorship: A Tribute to Lewis Cantley.

Cancer discovery·2026
Same author

Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i>.

Antimicrobial agents and chemotherapy·2026

Related Experiment Video

Updated: Jan 21, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

8.0K

Increased PHGDH expression promotes aberrant melanin accumulation.

Katherine R Mattaini1,2, Mark R Sullivan1,2, Allison N Lau1,2

  • 1Koch Institute for Integrative Cancer Research, Cambridge, 02139, MA, USA.

BMC Cancer
|July 24, 2019
PubMed
Summary

Increased D-3-phosphoglycerate dehydrogenase (PHGDH) expression in mice affects melanocyte biology, leading to early melanin production in hair follicles. However, elevated PHGDH alone does not cause cancer.

More Related Videos

Spray-Coated Melanin/PEDOT:PSS Films for Sustainable Organic Electrochemical Transistors
08:26

Spray-Coated Melanin/PEDOT:PSS Films for Sustainable Organic Electrochemical Transistors

Published on: October 28, 2025

497
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

8.0K
Spray-Coated Melanin/PEDOT:PSS Films for Sustainable Organic Electrochemical Transistors
08:26

Spray-Coated Melanin/PEDOT:PSS Films for Sustainable Organic Electrochemical Transistors

Published on: October 28, 2025

497
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.7K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Copy number gain of PHGDH, crucial for serine biosynthesis, is observed in certain cancers, including melanomas.
  • PHGDH encodes the rate-limiting enzyme in the de novo serine synthesis pathway.

Purpose of the Study:

  • To investigate the in vivo effects of elevated PHGDH expression on tissue biology.
  • To analyze the phenotypic consequences of inducible PHGDH overexpression.

Main Methods:

  • Generation of PHGDHtetO mice for doxycycline-inducible PHGDH expression.
  • Analysis of tissue and cellular phenotypes following PHGDH induction.
  • Histological examination of skin tissue and hair follicle cycling.

Main Results:

  • PHGDHtetO mice exhibited increased serine biosynthesis in tissues and cells.
  • Aberrant melanin granule presence was observed in early anagen hair follicles.
  • Increased melanocyte abundance in early anagen skin accompanied the melanin phenotype.

Conclusions:

  • Elevated PHGDH expression influences melanocyte biology and hair follicle pigmentation.
  • PHGDH overexpression alone is insufficient to induce cancer development.