Related Experiment Video

Updated: Jan 21, 2026

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.7K

The effectiveness and safety of Kami Guibi-tang for mild cognitive impairment: study protocol of a pilot, randomized,

Hee-Yeon Shin1,2, Jeong-Hwa Kim1,2, Geon-Ho Jahng3

  • 1Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Trials
|July 24, 2019
PubMed
Abstract

Insights

This study investigates Kami Guibi-tang (KGT) as a potential treatment for amnestic mild cognitive impairment (aMCI), a precursor to Alzheimer's disease. The randomized trial will assess KGT's effectiveness and safety over 24 weeks.

Area of Science:

  • Neurology
  • Pharmacology
  • Gerontology

Background:

  • Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia.
  • Amnestic MCI (aMCI) is a significant prodromal stage for Alzheimer's disease (AD), making it a critical target for intervention.
  • Currently, no approved treatments exist for MCI, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

  • To evaluate the efficacy and safety of Kami Guibi-tang (KGT), a traditional Korean herbal medicine, in patients with amnestic MCI.
  • To determine if KGT can improve cognitive function and alter brain metrics in individuals with aMCI.
  • To provide foundational data for future large-scale clinical trials investigating KGT for MCI treatment.

Main Methods:

  • A single-center, randomized, placebo-controlled, double-blind trial design.
  • Participants with amnestic MCI will receive either KGT or a placebo for 24 weeks.
  • Primary outcomes include changes in neuropsychological test scores (Seoul Neuropsychological Screening Battery) and MRI measurements (brain metabolites, neurotransmitters, cerebral blood flow).

Main Results:

  • The study is designed to collect data on the primary and secondary outcomes.
  • Safety will be assessed through blood chemistry and AD-related protein/cholesterol levels.
  • MRI changes will be analyzed, accounting for age and genetic factors.

Conclusions:

  • This trial represents the first clinical investigation into the therapeutic potential of Kami Guibi-tang for amnestic MCI.
  • The findings are expected to inform the design and feasibility of larger studies to establish KGT as a viable treatment option for MCI.
Keywords:
Brain metaboliteBrain neurotransmitterCerebral blood flow (CBF)Herbal medicineKami Guibi-tangMagnetic Resonance Imaging (MRI)Mild cognitive impairment (MCI)Seoul Neuropsychological Screening Battery (SNSB)

More Related Videos

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.6K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.2K
The Placebo Effect01:54

The Placebo Effect

The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.8K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
241
Pilot and Numeric Relaying01:21

Pilot and Numeric Relaying

Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
483