Related Experiment Video
Updated: Jan 21, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Operable ventricular septal defect despite severe pulmonary hypertension and cyanosis!
Shyam S Kothari1, Jay Relan1, Velayoudam Devagourou1
1Departments of Cardiology, and Cardiothoracic surgery, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
Patients with a significant left-to-right shunt at ventricular level may become inoperable at an early age due to irreversible pulmonary vascular disease. On the other hand, even suprasystemic pulmonary hypertension due to mitral stenosis remains treatable. We report a 24-year-old patient with large ventricular septal defect, severe mitral stenosis and cyanosis who improved after surgical correction of both the lesions. This emphasises the importance of additional post-capillary pulmonary hypertension in Eisenmenger syndrome.
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