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Knowing your GFR-when is the number not (exactly) the number?
Lesley A Inker1, Andrew S Levey1
1Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
Kidney International
|July 24, 2019
Summary
Biological variability in kidney function is greater for measured glomerular filtration rate (mGFR) than estimated glomerular filtration rate (eGFR). This impacts interpreting changes in kidney function over time.
Area of Science:
- Nephrology
- Renal Physiology
- Diagnostic Accuracy
Background:
- Glomerular filtration rate (GFR) assessment is crucial for diagnosing and managing kidney disease.
- Current GFR measurement and estimation methods have inherent errors, leading to discrepancies between measured GFR (mGFR) and estimated GFR (eGFR).
Purpose of the Study:
- To evaluate the time-to-time variability of both mGFR and eGFR using repeated assessments within a short period.
- To compare the biological variability between mGFR and eGFR.
- To determine the magnitude of reference change values for interpreting changes in GFR.
Main Methods:
- Repeated assessments of mGFR and eGFR were conducted within a short timeframe.
- Statistical analysis was performed to evaluate biological variability and reference change values.
Main Results:
- Biological variability was found to be larger for mGFR compared to eGFR.
- The study quantified the magnitude of reference change values for both mGFR and eGFR, highlighting differences in their interpretation.
Conclusions:
- Understanding the inherent variability of GFR measurements is essential for accurate clinical interpretation.
- The greater biological variability of mGFR necessitates careful consideration when monitoring kidney function changes over time.
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