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Updated: Jan 21, 2026
08:46
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
6.6K
Female fertility preservation in DSD
Rashi Kalra1, Melissa Cameron2, Catharyn Stern2
1Reproductive Services Unit, The Royal Women's Hospital, Parkville VIC 3052, Australia.
Summary
Disorders of Sex Development (DSD) impact fertility, with options ranging from cryopreservation to gamete donation. This review explores reproductive outcomes and fertility preservation strategies for DSD patients.
Area of Science:
- Reproductive Medicine
- Endocrinology
- Genetics
Background:
- Disorders of Sex Development (DSD) encompass conditions affecting chromosomal, gonadal, and phenotypic sex.
- Fertility potential varies significantly among individuals with DSD and Turner syndrome.
Purpose of the Study:
- To review fertility issues and reproductive outcomes in patients with DSD and Turner syndrome.
- To discuss fertility preservation methods for adolescent and prepubertal girls undergoing gonadotoxic treatment.
- To explore future directions and ethical considerations in fertility preservation for DSD.
Main Methods:
- Literature review of fertility and reproductive outcomes in DSD and Turner syndrome.
- Summary of established fertility preservation techniques.
- Discussion of alternative family-building options.
Main Results:
- Established fertility preservation options include ovarian tissue and oocyte cryopreservation.
- In many DSD cases, natural fertility is not possible.
- Alternative family-building methods like gamete donation and surrogacy are often necessary.
Conclusions:
- Fertility preservation is crucial for DSD patients, especially before gonadotoxic therapies.
- Ovarian tissue and oocyte cryopreservation offer viable options.
- For many, alternative reproductive technologies are essential for family planning.
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