Related Experiment Video
Updated: Jan 21, 2026
08:33
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
Published on: August 24, 2019
8.1K
Relationship Between Ascending Thoracic Aortic Aneurysms Hemodynamics and Biomechanical Properties
IEEE Transactions on Bio-Medical Engineering
|July 24, 2019
Summary
Low time-averaged wall shear stress (TAWSS) is linked to reduced rupture resistance in ascending thoracic aortic aneurysms (aTAA). This finding improves understanding of aTAA rupture risk and patient outcomes.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Medical Physics
Background:
- Ascending thoracic aortic aneurysm (aTAA) is a significant cause of mortality.
- The role of hemodynamics in aTAA rupture risk is not fully understood.
- Novel methodologies are needed to assess aTAA rupture risk.
Purpose of the Study:
- To develop and apply a novel methodology to assess the correlation between aTAA rupture risk and hemodynamic biomarkers.
- To combine in vivo, in vitro, and in silico analyses for a comprehensive assessment.
- To investigate the relationship between hemodynamic factors and biomechanical properties of aTAA.
Main Methods:
- Computational fluid dynamics (CFD) analyses were performed on patient-specific data from CT scans and 4D MRI.
- Hemodynamic biomarkers including TAWSS, flow eccentricity, and helicity intensity were assessed.
- In vitro bulge inflation tests on resected aTAA samples provided biomechanical and rupture properties.
Main Results:
- A highly significant positive correlation was found between rupture stretch (λrupt) and time-averaged wall shear stress (TAWSS) (r = 0.867, p = 0.001).
- Low TAWSS was statistically significantly correlated with reduced rupture properties in aTAAs.
- Multiple hemodynamic and biomechanical parameters were assessed and correlated.
Conclusions:
- Relatively low TAWSS is a significant predictor of reduced rupture properties in aTAAs.
- This study provides novel insights into the hemodynamic factors influencing aTAA rupture.
- Understanding these correlations is crucial for reducing aTAA morbidity and mortality.
Related Concept Videos
01:24Pressure Relationships in Thoracic Cavity
6.1K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
6.1K
02:12Relationship Formation
45.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.2K
01:15Thoracic Aorta
1.5K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.5K
01:28Ending Relationships
174
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
174
01:17The Thoracic Cage: Sternum
5.8K
The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
5.8K
01:20The Thoracic Cage: Ribs
8.2K
Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
8.2K