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Updated: Jan 21, 2026
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
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Recurrent fetal hydrops with maternal M alloimmunisation: not a benign condition
Michelle Yu1, Kathryn Graham1, Leonardo Pasalic2
1Department of Obstetrics & Gynaecology, Westmead Hospital, Westmead, New South Wales, Australia.
BMJ Case Reports
|July 24, 2019
Summary
M alloimmunisation can cause severe hemolytic disease in newborns, even with anti-M antibodies. This case highlights the need for careful fetal surveillance and monitoring during pregnancy.
Area of Science:
- Immunology
- Obstetrics
- Neonatology
Background:
- Hemolytic disease of the fetus and newborn (HDFN) is typically linked to red blood cell antibodies.
- Anti-M antibodies are generally associated with mild hemolysis and are rarely considered clinically significant.
Observation:
- A case of recurrent HDFN with maternal M alloimmunization was observed at an Australian tertiary hospital.
- This is the first reported instance of recurrent fetal hydrops due to M alloimmunization.
Findings:
- The affected neonate required intensive care, including intubation, ionotropic support, and blood and plasma transfusions.
- A positive direct Coombs test confirmed HDFN in the neonate.
Implications:
- Accurate patient history and vigilant fetal surveillance are crucial for detecting fetal anemia, even with anti-M antibodies.
- Concurrent placental disease may exacerbate fetal risks associated with anti-M antibodies.
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