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Updated: Jan 21, 2026
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Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
Published on: April 28, 2016
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Developmental topography of cortical thickness during infancy.
Fan Wang1,2, Chunfeng Lian1,2, Zhengwang Wu1,2
1Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Summary
Human brain cortical thickness develops dynamically in early childhood. This study reveals distinct developmental regions and patterns, offering insights into infant brain maturation and potential neurodevelopmental disorders.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Cortical thickness development is crucial for cognitive outcomes and vulnerable to disorders.
- Limited understanding exists on infant cortical thickness dynamics due to acquisition challenges.
Purpose of the Study:
- To identify developmental regionalization of cortical thickness in infants.
- To understand spatiotemporal heterogeneities in cortical thickness development.
- To provide insights into early brain development.
Main Methods:
- Utilized an infant-dedicated computational pipeline and non-negative matrix factorization.
- Analyzed 210 serial MRI scans from 43 healthy infants (1-24 months).
- Employed a densely sampled longitudinal dataset with 7 scans per infant.
Main Results:
- Whole-brain average cortical thickness plateaus around 14 months and then slowly decreases.
- Discovered structurally and functionally meaningful regions with distinct developmental patterns.
- Identified regions peaking at varied ages or continuously increasing throughout the first two years.
Conclusions:
- Cortical thickness development exhibits significant regional heterogeneity in early infancy.
- Distinct developmental trajectories exist for different brain regions.
- Findings offer valuable insights for understanding typical and atypical early brain development.
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