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Reply to 'Inflated performance measures in enhancer-promoter interaction-prediction methods'

Sean Whalen1, Katherine S Pollard2,3,4

  • 1Gladstone Institutes, San Francisco, CA, USA.

Nature Genetics
|July 24, 2019
PubMed
Summary

No abstract available in PubMed .

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...

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