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Published on: January 13, 2026
A Randomized Trial of Ultrasound- versus. Fluoroscopy-Guided Subclavian Vein Catheterization in Children with
Huajin Pang1, Yong Chen2, Xuehan Liu3
1Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China. nfyyphj@163.com.
Insights
Ultrasound guidance improves subclavian vein catheterization success in children with hematologic diseases. Combining ultrasound and fluoroscopy may offer the most efficient approach for this pediatric population.
Area of Science:
- Pediatric Hematology
- Vascular Access Procedures
- Medical Imaging Techniques
Background:
- Subclavian vein catheterization is crucial for pediatric patients with hematologic diseases.
- Accurate and safe venous access is essential for treatment delivery and patient outcomes.
- Current guidance methods include ultrasound and fluoroscopy, each with potential benefits and drawbacks.
Purpose of the Study:
- To compare the efficacy and safety of ultrasound-guided versus fluoroscopy-guided subclavian vein catheterization in pediatric patients with hematologic diseases.
- To evaluate key outcomes such as cannulation success, procedural time, and complication rates.
Main Methods:
- A randomized prospective study involving 170 pediatric patients with hematologic diseases.
- Patients were randomly assigned to either ultrasound-guided or fluoroscopy-guided subclavian vein catheterization.
- Primary outcome: number of attempts for venous cannulation; Secondary outcomes: success rate, fluoroscopy time, operation time, and complications.
Main Results:
- Ultrasound guidance resulted in a significantly higher success rate within 3 attempts (92.0%) compared to fluoroscopy (78.3%).
- No significant differences were observed in average operation time or overall surgical complications between the groups.
- While the fluoroscopy group had no catheter-related thrombosis (CRT), the ultrasound group had 4 CRTs during follow-up.
Conclusions:
- Ultrasound-guided venous puncture offers superior accuracy for subclavian vein catheterization in this pediatric cohort.
- Fluoroscopy provides greater precision for catheter tip placement.
- A combined ultrasound- and fluoroscopy-guided approach is suggested to enhance efficiency in subclavian vein catheterization for children with hematologic disease.
Objective:
To compare the ultrasound- and fluoroscopy-guided subclavian vein catheterization in pediatric population with hematologic diseases.
Methods:
A randomized prospective study of subclavian vein catheterization in pediatric population with hematologic diseases was performed. After randomization, the patients were assigned to either ultrasound- or fluoroscopy-guided subclavian vein catheterization. The primary outcome was number of attempts at venous cannulation. Secondary outcomes included: catheterization success rate, fluoroscopy time, operation time, and surgical complications.
Results:
There were 170 children enrolled between February 2017 and July 2018. There was no difference between the two groups with regard to the demographic data. Success within 3 attempts was achieved in 82 cases (82/87, 92.0%) in the ultrasound (US) group vs. 65 cases (65/83, 78.3%) in the fluoroscopy group (P = 0.002). The average operation time was 10(7) min in US group vs. 10(6) min in fluoroscopy group (P = 0.722). There were 3 complications in the US group, while there were 6 complications in the fluoroscopy group (P = 0.321). There were 4 catheter-related thrombosis (CRTs) found in the US group during follow-up, however there was no CRT in the fluoroscopy group (P = 0.121).
Conclusions:
Ultrasound-guided venous puncture is a more accurate method of subclavian vein catheterization. However, the catheter tip can be placed more precisely by fluoroscopy. Thus, combined ultrasound-and fluoroscopy-guided technology is more efficient in subclavian vein catheterization of children with hematologic disease.
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