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Dispersive Liquid-Liquid Microextraction Based on Solidification of Floating Organic Drop with Central Composite
Maryam Shirinnejad1, Amir H M Sarrafi2
1Research Laboratory of Analytical Chemistry, Department of Chemistry, Faculty of Science, Islamic Azad University Central Tehran Branch, Tehran, Iran.
Abstract:
A quick, simple and efficient method for extraction, preconcentration, and determination of naproxen in water and plasma specimens with acceptable recovery by dispersive liquid-liquid microextraction based on solidified floating organic drop with spectrofluorimetry is presented. Various parameters affecting the extraction efficiency are optimized by the Central Composite Design. Moreover, under optimal conditions (120 μL 1-Undecanol with 1 mL Ethanol, pH = 3.5, 2 mL KCl 10% solution), the calibration curve was linear in the range 10.0-120.0 ng/mL. Finally, for naproxen, the detection limit was 2.4 ng/mL.
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