Oxidative stress parameters in children with acute rheumatic fever

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Ayfer Gözü Pirinccioglu1, Ömer Alyan2, Alper Akin1

  • 1Department of Pediatrics, School of Medicine, Dicle University, Diyarbakır, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|July 24, 2019
PubMed

Insights

Oxidative stress markers like malondialdehyde and protein carbonyl are elevated in acute rheumatic fever (ARF) and correlate with disease severity. These markers, along with hs-CRP, can aid in ARF patient evaluation.

Area of Science:

  • Biochemistry
  • Immunology
  • Pediatrics

Background:

  • Acute rheumatic fever (ARF) is an inflammatory condition with potential long-term cardiac complications.
  • The role of oxidative stress (OS) in the pathogenesis and progression of ARF requires further elucidation.

Purpose of the Study:

  • To investigate the role of oxidative stress in ARF.
  • To explore the relationship between OS markers and disease progression in ARF patients.

Main Methods:

  • Serum levels of oxidative stress markers (malondialdehyde, protein carbonyl), hs-CRP, cytokines (TNF-α, IL-6), and total antioxidant capacity (TAC) were measured in 30 ARF patients and 31 healthy controls.
  • Correlation analyses were performed to assess relationships between OS markers, inflammation, and disease indicators.
  • Diagnosis of ARF was confirmed using the Jones criteria.

Main Results:

  • ARF patients exhibited significantly higher serum malondialdehyde (MDA), protein carbonyl (PCO), hs-CRP, and cytokine levels compared to controls.
  • Total antioxidant capacity (TAC) was significantly lower in ARF patients.
  • Oxidative stress markers positively correlated with hs-CRP and cytokines, while TAC showed negative correlations. Valve involvement severity was linked to OS parameters and TAC.
  • Anti-inflammatory therapy led to a significant decrease in OS markers and an increase in TAC.

Conclusions:

  • Malondialdehyde (MDA) and protein carbonyl (PCO) serve as valuable biomarkers for assessing oxidative stress in ARF.
  • Combined with hs-CRP and other diagnostic tools, MDA and PCO can aid in the clinical evaluation of ARF patients.
  • The findings highlight the significant contribution of oxidative stress to ARF pathophysiology and its potential as a therapeutic target.
Abstract

Keywords:
acute rheumatic feverlipid peroxidationoxidative stressprotein oxidationtotal antioxidant capacity

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