Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Function of the MHC.

E Simpson1

  • 1Transplantation Biology Section, Clinical Research Centre, Harrow, U.K.

Immunology. Supplement
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

The Major Histocompatibility Complex (MHC) controls tissue graft rejection and guides T-cell responses. Its genes and molecules play a crucial role in immune system interactions and cell signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benefits of Integrated Social Care in the Management of Patients With Inborn Errors of Metabolism.

JIMD reports·2025
Same author

Estimands for atopic dermatitis clinical trials: Expert opinion on the importance of intercurrent events.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Sickle cell bone disease and response to intravenous bisphosphonates in children.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

User attitudes towards virtual home assessment technologies.

Journal of medical engineering & technology·2022
Same author

Online KidClot education for patients and families initiating warfarin therapy: The eKITE study.

Thrombosis research·2022
Same author

Pioneering global best practices in atopic dermatitis: results from the atopic dermatitis quality of care initiative.

Clinical and experimental dermatology·2021
Same journal

Abstracts from the Annual Congress of the British Society for Immunology, 20-23 February 2007, Glasgow, United Kingdom.

Immunology. Supplement·2007
Same journal

Annual Congress of the British Society for Immunology, 6-9 December 2005, Harrogate, UK. Abstracts.

Immunology. Supplement·2005
Same journal

Joint Congress of the British Society for Immunology and the British Society for Allergy and Clinical Immunology, 3-6 December 2002, Harrogate, United Kingdom. Abstracts.

Immunology. Supplement·2002
Same journal

Annual Congress of the British Society for Immunology. 5-8 December 2000, Harrogate, United Kingdom. Abstracts.

Immunology. Supplement·2001
Same journal

Joint Congress of the British Society for Immunology and the British Society for Allergy and Clinical Immunology. Harrogate, United Kingdom, 30 November -3 December 1999. Abstracts.

Immunology. Supplement·2000
Same journal

6th Annual Congress of the British Society for Immunology. Harrogate, United Kingdom, 1-4 December 1998. Abstracts.

Immunology. Supplement·1999
See all related articles

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • The Major Histocompatibility Complex (MHC) was initially identified for its role in rapid tissue graft rejection.
  • Further studies revealed multiple linked loci within the MHC, including immune response (Ir) genes.

Purpose of the Study:

  • To elucidate the principal function of MHC molecules in the immune system.
  • To explore additional roles of MHC molecules beyond their known functions.

Main Methods:

  • In vivo studies of antibody responses.
  • In vitro studies of T-cell responses to MHC antigens.
  • Molecular identification of MHC genes and products.
  • Analysis of MHC association with cell surface receptors.

Related Experiment Videos

Main Results:

  • MHC molecules were identified as critical for controlling T-cell responses, a concept known as MHC restriction.
  • The study confirmed the presence of multiple closely linked loci within the MHC.
  • MHC molecules are implicated in guiding T-cell responses.

Conclusions:

  • The primary function of MHC molecules is to act as guidance molecules for T-cell responses.
  • Emerging evidence suggests additional functions for MHC molecules, potentially linked to cell surface receptors.