Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

68.0K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.0K
Factors Affecting Solubility04:01

Factors Affecting Solubility

36.7K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
36.7K
Solubility Equilibria03:07

Solubility Equilibria

56.8K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
56.8K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

26.2K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
26.2K
Solubility03:00

Solubility

21.0K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
21.0K
Chemical and Solubility Equilibria02:21

Chemical and Solubility Equilibria

4.9K
The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if  ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RANQSAR: a standalone open-source application for reproducible machine learning-based QSAR analysis.

Journal of computer-aided molecular design·2026
Same author

Assessing Compliance of Tobacco Advertisement Promotions and Sponsorship Ban in India: Challenges, Opportunities, and the Way Forward.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2026
Same author

Occupational tobacco exposure and multisystem morbidity among beedi rollers: biomarker-validated evidence from a multi-state study in India.

Frontiers in public health·2026
Same author

Older adults' perceptions of artificial intelligence in healthcare: an exploratory quantitative analysis.

The Gerontologist·2026
Same author

Influence of graphene oxide (GO) on thermo-mechanical performance of fly ash-steel slag based geopolymer composite: an experimental and numerical approach.

Scientific reports·2026
Same author

Understanding the Role of Communication in Deprescribing Behavior Change.

Journal of the American Geriatrics Society·2026

Related Experiment Video

Updated: Jan 21, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.5K

The Solubility-Permeability Interplay for Solubility-Enabling Oral Formulations.

Nidhi Nainwal1, Ranjit Singh2, Sunil Jawla2

  • 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Balawala, Dehradun, India.

Current Drug Targets
|July 24, 2019
PubMed
Summary

This review examines how solubility enhancement techniques impact drug intestinal permeability. Understanding these effects is crucial for developing effective drug formulations with good bioavailability.

Keywords:
Solubilitybiopharmaceuticalcyclodextrinhydrotropesintestinal permeabilitysolubility-permeability interplay.

More Related Videos

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

10.0K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.5K
Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

10.0K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.7K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Biopharmaceutics

Background:

  • The Biopharmaceutical Classification System (BCS) categorizes drugs by solubility and permeability, influencing bioavailability.
  • Many drugs exhibit poor solubility, necessitating enhancement strategies.
  • Solubility enhancement methods can inadvertently affect drug intestinal permeability, a critical factor for bioavailability.

Purpose of the Study:

  • To review the impact of various solubility enhancement approaches on drug intestinal permeability.
  • To highlight the importance of considering permeability changes when designing drug formulations.
  • To guide the development of optimized formulations balancing solubility and permeability.

Main Methods:

  • Literature review of solubility enhancement techniques.
  • Analysis of the effects of cyclodextrins, surfactants, cosolvents, hydrotropes, and amorphous solid dispersions on drug permeability.
  • Discussion of the implications for drug formulation design.

Main Results:

  • Various solubility enhancement strategies can alter drug intestinal permeability.
  • The specific impact on permeability varies depending on the technique and drug properties.
  • Careful formulation design is needed to maintain or improve permeability alongside solubility.

Conclusions:

  • Solubility enhancement is vital for improving drug bioavailability, but its effect on permeability must be carefully evaluated.
  • Techniques like cyclodextrin complexation, surfactant use, cosolvents, hydrotropes, and amorphous solid dispersions require assessment for their impact on intestinal permeability.
  • Optimized pharmaceutical formulations necessitate a balanced approach to solubility enhancement without compromising drug permeability.