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Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic

Leiliandry de Araújo Melo1, Maria Mariana Barros Melo da Silveira1, Isabelle Cecília de Vasconcellos Piscoya1

  • 1Faculdade de Ciencias Medicas/ Universidade de Pernambuco - FCM/UPE, Recife, Pernambuco, Brazil.

Microrna (Shariqah, United Arab Emirates)
|July 24, 2019
PubMed
Abstract

Insights

Downregulation of miR-133b may indicate Alcoholic Cardiomyopathy (ACM). miR-138 correlates with improved ejection fraction and left atrium diameter in ACM patients, suggesting potential diagnostic and prognostic value.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarkers

Background:

  • Alcoholic Cardiomyopathy (ACM) presents diagnostic challenges.
  • The precise pathophysiological mechanisms of ACM remain incompletely understood.

Purpose of the Study:

  • To investigate the potential association of miR-133b and miR-138 with Alcoholic Cardiomyopathy.
  • To explore the role of these microRNAs in ACM pathophysiology.

Main Methods:

  • Real-time PCR was employed to assess the relative expression of miR-133b and miR-138.
  • Statistical analyses included t-student, Mann-Whitney, Pearson correlation, and chi-square tests (p<0.05 significance).
  • Forty-four patients were analyzed: 24 with ACM and 20 in a control group with other cardiomyopathies.

Main Results:

  • Patients with ACM exhibited significant downregulation of miR-133b compared to controls (p=0.004).
  • No significant association was found for miR-138 between the ACM and control groups.
  • In ACM patients, increased miR-138 expression correlated with enhanced ejection fraction (r=0.28, p=0.01) and left atrium diameter (r=0.23, p=0.04).

Conclusions:

  • Downregulation of miR-133b may serve as a potential diagnostic biomarker for ACM.
  • miR-138 shows potential for correlating with improved ejection fraction and normalized left atrium diameter in ACM patients.
Keywords:
Alcoholic cardiomyopathybiomarkerscardiomegalyechocardiographyfibrosismicroRNA.

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